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We are indebted to Niall Quinn and Anette Schrag for reviewing the data on adverse events; to Jason Gardner, Julian Keens, and Sandy Macrae for their assistance in the development of the manuscript; to Mary Oldham and Jacquie Warner for performing all statistical analyses; and to all the coinvestigators and nurses who participated in the study.

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It significantly reduces “off” time an average of 40% and increases total “on” time by about 25% at all dose levels.

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MAO-B, by contrast, is found in non-neuron brain cells (glia cells called astrocytes) and is more effective in breaking down the neurotransmitter dopamine.

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After LSVT, patients with Parkinson disease speak at a normal volume and with a healthy voice quality despite the need to "think loud, think shout.

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